![]() If he or she finds swollen lymph nodes, it means the body is mounting a response to an infection, explains Dr. Why does this happen? The lymphatic system is home to your immune system so when you get checked out for a cold or strep throat or flu, your doctor will feel your neck area. Swollen lymph nodes: What you need to knowĪ COVID-19 vaccine can cause enlarged lymph nodes in your armpit or near your collarbone on the side of your body where you received the injection. The Johnson & Johnson vaccine uses a different “carrier” approach, and there have not been any reports of those particular types of reactions. So far, swollen lymph nodes and skin reactions have only been detected in those who have received Moderna and Pfizer-BioNTech vaccines, both of which use a type of technology called mRNA (messenger RNA). “As more people get vaccinated, it’s important to allay fears and avoid unnecessary testing or treatment for conditions that should quickly resolve,” says Brita Roy, MD, MPH, an internal medicine physician and director of population health for Yale Medicine. Because information about COVID-19 changes rapidly, we encourage you to visit the websites of the Centers for Disease Control & Prevention (CDC), World Health Organization (WHO), and your state and local government for the latest information.Įven if you haven’t received a COVID-19 vaccine, you are likely aware of the common side effects associated with any vaccine, including sore arm and fatigue.īut you may not realize that COVID-19 vaccination can also cause other harmless side effects, including swollen lymph nodes or an unsightly arm rash-sometimes called “COVID arm.” Because these reactions are normal, medical experts want to get the word out to avoid any alarm for those who experience such symptoms. Frequency of the most common manifestations of local injection-site reactions, by dose, were swelling (18% and 15%), erythema (18% and 20%), and pain (24% and 18%).Note: Information in this article was accurate at the time of original publication. Local injection-site reactions occurred after 24% and 25% of first and second doses, respectively. ![]() Delayed large local reactions occurred after 15% of first doses and after 18% of second doses. ![]() The Pfizer subgroup represented a smaller sample size (34 first-dose reports and 40 second-dose reports), but the pattern of skin reactions was similar to that observed with the Moderna vaccine. No other type of reaction occurred in more than 1%-2% of patients after either dose. Erythromelalgia occurred after 5.9% of second doses, and cosmetic filler reactions occurred after 4.9% of second doses. Measles-like morbilliform rash occurred after the first dose of Moderna vaccine in 4.1% of patients and after the second dose in 6.9%. An additional 2% of patients developed urticaria within the first 24 hours (all after the second dose). In most cases, the rash arose more than 24 hours after dosing (4.8% after the first dose, 4.9% after the second). Urticaria was the next most common type of skin reaction associated with the Moderna vaccine. Registry participants collected information on the type and timing of vaccine doses and the morphology, timing, duration, and treatment of reactions. "Understandably, the clinical trials were focused on their major endpoints and didn't really provide a lot of detail on the skin reactions seen in patients."Įstablished in March 2020 to accumulate information on cutaneous manifestations of COVID-19, the registry expanded in December to include vaccine-related skin reactions, shortly after the FDA issued the first emergency use authorizations (EUAs) for the vaccines. "We have been involved with following skin reactions to COVID-19 vaccines, but the paper is pretty novel in that it covers a whole range of reactions that had not been reported from vaccine clinical trials," registry principal investigator Esther Freeman, MD, PhD, of Massachusetts General Hospital in Boston, told MedPage Today. They were discussed during the recent AAD virtual meeting and published simultaneously in the Journal of the American Academy of Dermatology. The findings came from the COVID-19 Dermatology Registry, a joint effort of the American Academy of Dermatology (AAD) and the International League of Dermatologic Societies.
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